Garlic extract may work just as well in mouthwash as some of the most widely used antiseptics according to new research. Although garlic-based mouthwash can be more uncomfortable to use, it may offer longer-lasting effects than chlorhexidine, one of the most commonly prescribed antimicrobial rinses. Chlorhexidine is widely used as a gold standard mouthwash but is associated with side effects and concerns over antimicrobial resistance. Garlic (Allium sativum), known for natural antimicrobial properties, has emerged as a potential alternative. Studies show that stronger concentrations of garlic extract mouthwash performed about as well as chlorhexidine in fighting microbes. Some studies favored chlorhexidine for maintaining higher plaque/salivary pH, while others reported garlic extract to be more effective at certain concentrations. However, garlic mouthwash may cause greater discomfort. Side effects of garlic mouthwash — such as a burning sensation and strong odor — were noted, though they tended to be less severe than the side effects associated with chemical agents like chlorhexidine. Still, these reactions may discourage some patients from switching. For now, garlic mouthwash shows real promise, but more science is needed before it can replace established treatments.
